Portada del libro de Identification and Evaluation of biomarkers to detect bladder cancer
Título del libro:

Identification and Evaluation of biomarkers to detect bladder cancer

LAP LAMBERT Academic Publishing (2015-02-13 )

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ISBN-13:

978-3-659-58940-9

ISBN-10:
3659589403
EAN:
9783659589409
Idioma del libro:
Inglés
Notas y citas / Texto breve:
Urinary Bladder Cancer (UBC) is the 5th most common cancer in the West. Continuous efforts have been made to develop non-invasive urine-based biomarkers with high sensitivity and specificity that would improve patients’ quality of life, costs and lower the number of cystoscopies. This can then be utilized as part of a multi-biomarker panel to develop a urine test for UBC diagnosis as a single marker is unable to replace current diagnostic invasive tools. Using a (LC-MS/MS) proteomic approach, 8 UBC and 1 normal bladder cell secretomes were analysed to identify secreted proteins that can be potential candidate biomarkers. phorbol 12-myristate 13-acetate (PMA; PKC activator was used to treat whole secretomes and investigate all proteins released by cells whereas secretomes that were treated with the broad-spectrum inhibitor, Marimastat underwent ultracentrifugation to focus on proteins being shedded. Protein quantification was based upon stable isotope labelling by peptide demethylation. Two methods were utilized to select candidate biomarkers: Human Protein Atlas and Ingenuity Pathway Analysis. EpCAM biology was also examined to see the effects of PMA and Marimastat on its ectodomain.
Editorial:
LAP LAMBERT Academic Publishing
Sitio web:
https://www.lap-publishing.com/
Por (autor):
Hafsa W. Abbas
Número de páginas:
252
Publicado en:
2015-02-13
Stock:
Disponible
Categoría:
Medicina
Precio:
55.90 €
Palabras clave:
Oncology, cancer, Bladder cancer, diagnosis, biomarkers, Adam, biology, Bladder, Gene Ontology, mass spectrometry, MMP, Proteomic, Urology, EpCAM, secretomes, MMP1, PMA, Marimastat, ADAM17

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