Glycol Nucleic Acid
978-613-2-81884-3
6132818847
116
2010-09-13
39.00 €
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Glycol nucleic acid is a polymer similar to DNA or RNA but differing in the composition of its "backbone". GNA is not known to occur naturally. The 2,3-dihydroxypropylnucleoside analogues were first prepared by Ueda et al. Soon thereafter it was shown that phosphate-linked oligomers of the analogues did in fact exhibit hypochromicity in the presence of RNA and DNA in solution. The preparation of the polymers was later described by Cook et al. and Acevedo and Andrews. The GNA-GNA self-pairing described by Zhang and Meggers is however novel, and the specificity of interaction well-demonstrated, the molecules themselves. DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas GNA's backbone is composed of repeating glycerol units linked by phosphodiester bonds.
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Biología
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