Portada del libro de Glutamate Receptor Dysfunction in Models of Alzheimer's Disease
Título del libro:

Glutamate Receptor Dysfunction in Models of Alzheimer's Disease

The Role of Glutamate Receptors in Neurodegeneration

VDM Verlag Dr. Müller (2009-04-07 )

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ISBN-13:

978-3-639-13192-5

ISBN-10:
3639131924
EAN:
9783639131925
Idioma del libro:
Inglés
Notas y citas / Texto breve:
The complexity of cognitive decline in Alzheimer’s disease warrants for a thorough investigation into the molecular mechanism that lead to impaired learning and memory. Certain molecules have been suggested to play significant roles in AD progression including two major hallmarks of AD, amyloid beta and tau proteins.The two may interact with some neurotransmitter systems involved in learning and memory to cause neurodegeneration. The most common and well studied neurotransmitter systems are the cholinergic and glutamatergic systems. Indeed, appropriate expression and function of glutamate receptors are important in cognitive processes. It is possible that these hallmarks and neurotransmitter systems work synergistically to execute the cognitive decline observed in AD.It is therefore important to unravel the early events that lead to the cascade of events prior to the overt signs of cognitive decline. Tissue and animal models have been used by several investigators. The model of choice depends on the intended target point in the neuropathological cascade. The study in this book utilized AD models to elucidate the early events of neurodegeneration
Editorial:
VDM Verlag Dr. Müller
Sitio web:
http://www.vdm-verlag.de
Por (autor):
Patrick Kanju
Número de páginas:
220
Publicado en:
2009-04-07
Stock:
Disponible
Categoría:
Biología
Precio:
79.00 €
Palabras clave:
"Alzheimer''s Disease" "Glutamates Receptors" "Electrophysiology" "Neurodegeneration" "Patch Clamp" "AMPA Receptors" "Synaptic Currents" "Ampakine" "Cholinergic Denervation""Medial Septum", "Alzheimer''s Disease" "Glutamates Receptors" "Electrophysiology" "Neurodegeneration" "Patch Clamp" "AMPA Receptors" "Synaptic Currents" "Ampakine" "Cholinergic Denervation""Medial Septum"

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