Portada del libro de Gamete Proteomics
Título del libro:

Gamete Proteomics

Analysis of the human sperm proteome

LAP LAMBERT Academic Publishing (2012-10-10 )

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ISBN-13:

978-3-659-24335-6

ISBN-10:
3659243353
EAN:
9783659243356
Idioma del libro:
Inglés
Notas y citas / Texto breve:
This book reviews a series of functional and immunological studies of the human sperm proteome. Two of the most cited studies originate from the examination of capacitation-induced protein modifications, which led to the cloning and characterisation of two new phospho-regulated cancer-testis antigens, named AKAP3 and CABYR. AKAP3 is a member of the A kinase anchoring protein-family, which provides spatial and temporal specificity to the cAMP-PKA pathway. In addition to scaffolding PKA, PDE and protein phosphatases, AKAP members also bind proteins that share homology to the RII dimerization/docking (R2D2) domain of PKA’ regulatory subunit. CABYR likewise interacts with a diverse array of signal tranducer molecules via its SH3-, R2D2-, and proline-rich extension-like domains. AKAP3 and CABYR associate in high molecular weight multi-protein complexes, which appear to regulate the energy supply to and motion of the sperm flagellum. The putative functional role of the CABYR signalling scaffold in cancer cells is discussed.
Editorial:
LAP LAMBERT Academic Publishing
Sitio web:
https://www.lap-publishing.com/
Por (autor):
Søren Naaby-Hansen
Número de páginas:
116
Publicado en:
2012-10-10
Stock:
Disponible
Categoría:
Otros
Precio:
49.00 €
Palabras clave:
Proteomics, capacitation, Autoimmunity, Gamete, fertilization

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