Portada del libro de Antiapoptotic Strategies in Retinal Degeneration
Título del libro:

Antiapoptotic Strategies in Retinal Degeneration

LAP LAMBERT Academic Publishing (2013-05-11 )

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ISBN-13:

978-3-659-39599-4

ISBN-10:
3659395994
EAN:
9783659395994
Idioma del libro:
Inglés
Notas y citas / Texto breve:
The sphingolipid ceramide exerts a pro-apoptotic role in variety of cellular and organ systems and increased of de-novo synthesis of ceramide are associated with initiation of cell death. In Retinitis Pigmentosa (RP) photoreceptor death occurs by apoptosis but the individual pathways of this process are unknown. We employed an animal model of RP, the rd10 mutant mouse, to assess the role of ceramide in inherited photoreceptor degeneration. We used Myriocin, a known inhibitor of serine palmitoyltransferase (SPT, the rate-limiting enzyme of ceramide biosynthesis) which was either injected intravitreally in a single dose or administered daily to rd10 mice as eye drops of Solid Lipid Nanoparti- cles (SLNs). Control mice were given intravitreal injections of vehicle alone or unloaded lipid particles, respectively. We found that retinal ceramide levels in rd10 mice double from P14 to P30, the time interval of maximum photoreceptor death in this strain. Intraocular treatment with Myriocin decreases the number of pycnotic photoreceptors in rd10 mice by approximately 50%. Electroretino- gram (ERG) recordings were obtained from animals of various ages chronically treated with Myriocin-SLNs.
Editorial:
LAP LAMBERT Academic Publishing
Sitio web:
https://www.lap-publishing.com/
Por (autor):
Ilaria Piano, Claudia Gargini
Número de páginas:
72
Publicado en:
2013-05-11
Stock:
Disponible
Categoría:
Biología
Precio:
62.24 $
Palabras clave:
apoptosis, retina, Drug Therapy, Electroretinogram, Serine-Palmitoyltransferase, Retinitis pigmentosa, CERAMIDE

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