Buchcover von Fighting Cancer Using Molecular Modeling and NMR Spectroscopy
Buchtitel:

Fighting Cancer Using Molecular Modeling and NMR Spectroscopy

LAP LAMBERT Academic Publishing (17.02.2015 )

Books loader

Omni badge gutscheinfähig
ISBN-13:

978-3-659-64725-3

ISBN-10:
365964725X
EAN:
9783659647253
Buchsprache:
Englisch
Klappentext:
Within the vast weaponry of available chemotherapies, one in particular, the targeted therapy, has captivated the interest and research efforts of many pharmaceutical companies and universities around the globe in the last 20 years. Developing drugs capable of interrupting one or more key oncogenic pathways in a specific fashion, has offered the opportunity of doubling the overall survival time and cure chances of millions of patients today. Among these drugs, we find those inhibiting the mitogenic signal activated by the Human Epidermal growth factor Receptor 2 (HER2), determinant of a very aggressive type of breast and gastric cancer. This work aims at developing new small molecules able to block the interaction of HER2 with its adapter protein Grb2 in order to prevent its oncogenic signal from reaching the cell nucleus and unleashing a typical overstimulated mitosis. To do so, we have followed a rational drug design supported by an NMR-guided optimization and a series of biological assays that finally led us to non-peptide compounds competent to selectively bind the Grb2 protein. I hope you find this book interesting and in some way helpful to your own research.
Verlag:
LAP LAMBERT Academic Publishing
Webseite:
https://www.lap-publishing.com/
von (Autor):
Angel Lorenzo Orcajo Rincón
Seitenanzahl:
132
Veröffentlicht am:
17.02.2015
Lagerbestand:
Lieferbar
Kategorie:
Organische Chemie
Preis:
61,90 €
Stichworte:
organic synthesis, HER2, Grb2, Targeted Chemotherapy, rational drug design, HSQC, breast cancer

Books loader

Newsletter

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Paypal Überweisung

  0 Produkte im Warenkorb
Warenkorb bearbeiten
Loading frontend
LOADING