Towards a functional proteomics approach to the comprehension of ILD的封面
书籍主题:

Towards a functional proteomics approach to the comprehension of ILD

Comparison of BALF proteome from interstitial lung diseases:Sarcoidosis, IPF, PLCH, fibrosis associated to SSc

Edizioni Accademiche Italiane (2017-09-28 )

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ISBN-13:

978-3-330-78337-9

ISBN-10:
3330783370
EAN:
9783330783379
书籍语言:
作品简介:
Bronchoalveolar lavage fluid of patients with four interstitial lung diseases (sarcoidosis, idiopathic pulmonary fibrosis, pulmonary Langerhans cell histiocytosis, fibrosis associated to systemic sclerosis) and smoker and non smoker control subjects were compared in a proteomic study. Principal Component Analysis was used to statistically verify the association between differentially expressed proteins and the conditions analyzed. Pathway and functional analysis by MetaCore and DAVID software revealed possible regulatory factors involved in specific “process networks” like regulation of stress and inflammatory responses. Immune response by alternative complement pathways, protein folding, Slit-Robo signalling and blood coagulation were “pathway maps” possibly associated with interstitial lung diseases pathogenesis. Four interesting proteins plastin 2, annexin A3, 14-3-3ε and S10A6 (calcyclin) were validated by western blot analysis. In conclusion, we identified proteins that could be directly or indirectly linked to the pathophysiology of the different interstitial lung diseases.
出版社 :
Edizioni Accademiche Italiane
网址:
https://www.edizioni-ai.com/
由(作者):
Claudia Landi
页码 :
100
发表日期:
2017-09-28
现货:
备有现货
类别:
生物化学 ,生物物理学
价格:
49.90 €
关键词:
proteomica, malattie polmonari interstiziali

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