Self Microemulsifying Drug Delivery System For Some Drugs的封面
书籍主题:

Self Microemulsifying Drug Delivery System For Some Drugs

Development And Evaluation Of Self Microemulsifying Drug Delivery System For High Molecular Weight Drugs

LAP LAMBERT Academic Publishing (2014-09-05 )

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ISBN-13:

978-3-659-59514-1

ISBN-10:
3659595144
EAN:
9783659595141
书籍语言:
英文
作品简介:
BCS class II are poorly water soluble and some drugs have high molecular weight, more than eleven hydrogen bond acceptors, more than five hydrogen bond doner. Thus, it exhibits poor bioavailability. A new Solid-Self Emulsifying Drug Delivery System (S-SMEDDS) of Drugs has been successfully developed to enhance its oral bioavailability by improving its solubility and facilitating high molecular weight of Drugs absorption. The primary composition of SMEDDS formulation was selected from solubility, pseudoternary phase diagram, emulsifying efficiency and compatibility test for preparation of (L-SMEDDS). Drug loaded L-SMEDDS were prepared in different concentration of oil, surfactant/co-surfactant and optimized by various evolutionary parameter such as robustness to dilution, drug content, ultrasonic interferometer, ease of emulsification, droplet size and in vitro diffusion study. The optimized L-SMEDDS converted into free flowing granules by spray drying technique. S-SMEDDS powder undergoes for characterization and confirmed the no interaction between drug and excipients.Thus, the present investigation improved the oral bioavailability of Drugs.
出版社 :
LAP LAMBERT Academic Publishing
网址:
https://www.lap-publishing.com/
由(作者):
Vikrant Wankhade
页码 :
280
发表日期:
2014-09-05
现货:
备有现货
类别:
药学
价格:
82.90 €
关键词:
SMEDDS, In-vivo study, Biovailability, pharmacokinetic parameters, ultrasonic resonance technology, Spray drier technology, Microemulsion

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