9783659142932

Synthesized pyrazoline-carbothioamide as potent antitubercular agent

Dhrubo Jyoti Sen, Ravichandra G. Patel
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ISBN-13:

978-3-659-14293-2

ISBN-10:
365914293X
EAN:
9783659142932
Book language:
English
Blurb/Shorttext:
A brief introduction of M.tuberculosis has been summarized. Pharmacological importance and literature survey of pyrazolo derivatives has been summarized. All the synthesized compounds were characterized by UV, IR, Mass and 1H-NMRspectroscopy. All the newly synthesized compounds have been screened for antibacterial activity. Streptomycin was used as standard reference drug. Compound 57b has been found to have better antibacterial activity against gram+ve bacteria S.aureus and B.subtilis as compared to other synthesized compounds. Compounds 57b, 58a, 58b have been found to have better activity against gram-ve bacteria. None of the compound has been found to be equipotent with standard streptomycin. All the newly synthesized compounds were screened for antitubercular activity. Compound 57b has been found to be most potent among the series having MIC 6.25 µg/ml. Others synthesised compounds have been found to be active (having MIC 57a: 500 µg/ml, 57c: 25 µg/ml, 58a: 25 µg/ml, 58b: 62.5 µg/ml, 58c: 250 µg/ml). None of the compound has been found to be equipotent with standard isoniazid.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Dhrubo Jyoti Sen, Ravichandra G. Patel
Number of pages:
68
Published on:
2012-05-30
Stock:
Available
Category:
Pharmacy
Price:
49.00 €
Keywords:
Polymerase Chain Reaction, major histocompatibility complex, tumour necrosis factor, Ultra Violet, Cell mediated immune, Antibody mediated immune, Multiple drug resistant tuberculosis, Mycobacterium growth indicator tubes, Bacillus Calmette-Guérin, Directed observed treatment short course

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