9783847325413

Reaction monitoring by DPPH

Dhrubo Jyoti Sen, Viraj P. Jatakiya, R. Badmanaban
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ISBN-13:

978-3-8473-2541-3

ISBN-10:
3847325418
EAN:
9783847325413
Book language:
English
Blurb/Shorttext:
The project work focuses on the organic reaction monitoring by DPPH on the synthesised eight compounds of two series having variable electronegative atoms X=O/S/NH which have been screened for CNS depression study by synergistic activity by standard drug. This project is a comparison between the SAR study with antioxidant potentiality by DPPH by using logP values with IC50 values with lambda max in UV.The logP value of 4-carboxamido phenyl thio urea (-0.31) is lesser than 2-carboxy phenyl thiourea (1.53) , so the same property arises during potentiality of lmax in UV. The logP value of 4-carboxy phenyl thiourea (0.84) is greater than 2-carboxamido phenyl urea (0.47), so antioxidant potentiality of IC50 value for 2-carboxamido phenyl urea is -661.18 ppm which is more effective than 4-carboxy phenyl thiourea which is 43.79 ppm.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Dhrubo Jyoti Sen, Viraj P. Jatakiya, R. Badmanaban
Number of pages:
80
Published on:
2012-01-06
Stock:
Available
Category:
Pharmacy
Price:
49.00 €
Keywords:
DPPH, Crocin bleaching assay, IOU, ORAC, TEAC, FRAP, copper(II) reduction capacity, Folin-Ciocalteu reagent, TOSC, Briggs-Rauscher oscillation reaction, chemiluminescence, Electrochemiluminescence, DMPD, BHA, antioxidant, Phenyl urea/thiourea (carboxylic acid/carboxamide), logP, IC50, Electronegativity, Trap

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