9783848488971

Neurochemistry of Schiff Base Pharmacophore for Caffeine

Dhrubo Jyoti Sen, Viraj Pareshbhai Jatakiya , Kartik Rasikbhai Patel
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ISBN-13:

978-3-8484-8897-1

ISBN-10:
3848488973
EAN:
9783848488971
Langue du livre:
Anglais
texte du rabat:
The CNS stimulation study has been performed on the two semisynthetic adducts of caffeine with Schiff’s base of pyrazolone and pyrazolone-pyrimidine nucleus. All the reference drugs and test compounds showed positive effect on CNS stimulation. The conclusion has been drawn from the fact that CNS stimulation effect for pentylene tetrazole is higher than caffeine, Molecule-I (pyrazolone ring) is less active than Molecule-II as the Molecule-II (pyrazolo-pyrimidine ring) is fused ring heterocyclic compound and the synergistic action with caffeine with Molecule-I having less activity than the Molecule-II but in case of leptazol (pentylenetetrazol), the synergistic activity of the two test compounds are equal but less than leptazol itself. The azole group is present in both caffeine and in leptazol but in fused ring heterocyclic chromophore and the same ring has been implemented in the two test compounds which have been semisynthesized by formation of Schiff’s base of caffeine to keep the similar bioisosteric nature. So, the components that have been semisynthesized showed the specific CNS stimulation activity.
Maison d'édition:
LAP LAMBERT Academic Publishing
Site Web:
https://www.lap-publishing.com/
de (auteur) :
Dhrubo Jyoti Sen, Viraj Pareshbhai Jatakiya , Kartik Rasikbhai Patel
Numéro de pages:
68
Publié le:
12-04-2012
Stock:
Disponible
Catégorie:
Pharmacie
Prix:
49.00 €
Mots-clés:
caffeine, Pyrazolone, pyrazolo-pyrimidine, leptazol, CNS stimulation

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