9783659104473

Schizophrenia a psychological disorder treatment and future aspects

Ishan I. Panchal, Dhrubo Jyoti Sen, Samir K. Shah
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ISBN-13:

978-3-659-10447-3

ISBN-10:
3659104477
EAN:
9783659104473
Langue du livre:
Anglais
texte du rabat:
New strategies for treatment of schizophrenia covers Agonists at the glycine and glutamate site of NMDA receptors include the naturally occurring amino acids glycine and D-serine. An analogue of D-serine, called D-cycloserine is also active at the glycine co-agonist site of NMDA receptors. All of these agents have been tested in schizophrenia with evidence that they can reduce negative and/or cognitive symptoms. The GLY-T1 reuptake pump is the major route of inactivation of synaptic glycine, so it is logical to explore the ability of GLY-T1 inhibitors to enhance synaptic actions of glycine, and, thus, of NMDA receptors. GLY-T1 pumps inhibit reuptake of other neurotransmitters which are blocked by a GLY-T1 inhibitor and this increases the synaptic availability of glycine and thus enhances NMDA neurotransmission.
Maison d'édition:
LAP LAMBERT Academic Publishing
Site Web:
https://www.lap-publishing.com/
de (auteur) :
Ishan I. Panchal, Dhrubo Jyoti Sen, Samir K. Shah
Numéro de pages:
64
Publié le:
02-10-2012
Stock:
Disponible
Catégorie:
Pharmacie
Prix:
49.00 €
Mots-clés:
schizophrenia, NMDA Receptor, Antipsychotic medication, GLY-T1 inhibitor

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